Emil M Friedman, PhD -
Consulting, Teaching & Tutoring
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Biostatistics, Statistics |
emilfrie@alumni.princeton.edu
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NOTE: I am a full-time employee of the MannKind
Corporation. However, I can handle
moderate size projects for independent clients on weekends or evenings if they
do not present a conflict of priorities or interest.
Experienced statistician - strong background in chemistry, polymer
science & engineering.
Consulting projects have covered wide variety of (often unique) situations.
Internal statistical consultant for R&D and manufacturing
plants. Led collaborative teams to:
define questions and design
experiments to answer them,
improve processes & products,
diagnose & solve wide range of technical & quality problems,
remove unnecessary constraints and work around necessary ones.
Devised curriculum & successfully taught applied statistics in
industry and online.
Extensive experience with JMP, SAS, and other software.
Invented and developed emulsion polymers & polymer processes to
satisfy product needs.
Extensive experience with wide variety of statistical methods.
EXPERIENCE:
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Novel
pharmaceutical stability studies
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Design
& analysis of experiments
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Analysis
of available data
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Representative
to IPAC-RS Delivered Dose Uniformity (DDU) Working Group
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Design of experiments & multiple
criteria optimization for chemical processes.
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Modeled pharmaceutical stability, set
tolerance intervals, recommended methodologies, etc.
·
Validated complex SAS program for
Peto-Pike carcinogenicity studies.
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Devised ad hoc sampling plan for unusual situation faced by other
statisticians.
·
Developed and simulated (using SAS)
Pepsi's "Match 3 for a Tee" game.
·
Modeled tire aging for Akron Rubber
Development Lab (analogous to Rx stability above).
·
Calculated odds of winning various
promotional games.
·
Designed & analyzed experiments
to test new method of removing secretions from endotracheal tubes.
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Designed & analyzed trials to
prevent infection by Israel Acute Paralysis Virus.
·
Interpreted statistical aspects of
DNA data for counsel in criminal trial.
·
Identified unexpected spatial
component in agricultural data.
(http://statisticalconsulting.org/Shafir.pdf)
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Designed and analyzed experiments
related to smoke density & heat release (Schneller, Inc).
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Statistically modeled market prices
for Booz-Allen-Hamilton.
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Cluster and related analyses for
marketing firm.
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Distributional analysis for jitter in
oscilloscopes.
SAS Institute, Contract Instructor
(Statistics Using JMP Software) 2003
to 2005
“Goodyear Spirit Award”,
1989.
Quotes from performance appraisals: “…recognized and much-sought internal consultant and expert in statistical methods and their application to real problem solving….Excellent listener and dissector of the key needs/wishes of his customers….Focuses their work to answer their desired questions, and creates experimental approaches specific to each problem.” “Emil has internalized the principals of Total Quality Culture”.
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Chaired curriculum committee. Developed, wrote and taught many portions of
internal statistics courses, including workshop in Multiple Criteria
Optimization. Associates consistently said that I made previously difficult
concepts easy to understand.
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Reduced measurement variation in
production process by a factor of 10. Team leader, Race Tire Advanced
·
Identified root cause of expensive
adhesion difficulties.
·
Prevented expensive (>$500,000/yr)
& unnecessary change in bladder compound.
Extensive experience with wide variety of statistical methods (eg, designed experiments, linear & non-linear regression, assessing measurement systems, sources of variation, Multiple Criteria Optimization, happenstance data, mixed models, ANOVA, ANOCOVA).
Identified root causes of major polymer deficiencies and devised improvements.
Synthesized polymers to meet specific needs. Software development as needed.
Polymer Science Dept, Univ of Mass (Roger S Porter) Post-doctoral research position, 1973-74
Other Activities:
Regional Chair, MIT Educational Council ?-2005
Math tutor - supposedly “lost” students achieved A’s in 11th grade math. 2004
Member, American Chemical Soc, American
Statistical Assoc
EDUCATION:
Massachusetts Institute of
Technology, Chemical Physics, BS. 1968
PRESENTATIONS:
Invited speaker, ASM International (Akron
Chapter), Akron Rubber Group Lecture
Series (twice), national meeting
of American Chemical Society. Many
internal seminars.
4,254013 4,574,140
4,960,819 5,162,425
PUBLICATIONS:
"Challenges and Opportunities in Implementing the
FDA Default Parametric Tolerance Interval Two-One Sided Test for Delivered Dose
Uniformity of Orally Inhaled Products", Greg Larner, Andrew Cooper,
Svetlana Lyapustina, Stefan Leiner, David Christopher, Helen Strickland,
Michael Golden, Hans-Joachim Delzeit, Emil M. Friedman. AAPS
PharmaSciTech online first: http://www.springerlink.com/content/f0175288762377v1/
“Stability
Models for Sequential Storage”, Emil M Friedman and Sam C Shum. AAPS
PharmaSciTech , vol 12, pp 96-103 (2011).
DOI 10.1208/s12249-010-9558-x. (http://statisticalconsulting.org/Stability_Sequential.pdf) Poster by Emil M Friedman at 33rd Annual Midwest Biopharmaceutical
Statistics Workshop,
“Inspiratory Efforts Achieved in Use of the
Technosphere® Insulin Inhalation System”,
“NIR Chemical Imaging to Guide/Support BMS-561389
Tablet Formulation Development”, L. Hilden, C.J. Pommiera, S. Badawya, Emil M.
Friedman, International Journal of
Pharmaceutics, 353(1-2), 283
(2008). http://dx.doi.org/10.1016/j.ijpharm.2007.11.032
“Modality of Molecular Weight Distributions”, Emil M
Friedman, Polymer Engineering and
Science, 30, 569 (1990). http://dx.doi.org/10.1002/pen.760301002
“High Conversion Emulsion Polymerization in a
Continuous Reactor: Predictions Using
Smith-Ewart Kinetics”, Emil M Friedman, J
Polymer Sci, Polym Phys Ed, 18, 1771 (1980). http://dx.doi.org/10.1002/pol.1980.180180809
“Elastomer Blends – Improved Strength…of Uncured
Rubber Compounds”, Emil M Friedman, Richard G Bauer, and Diego C Rubio, in Polymer Alloys, ed D Klempner and K C
Frisch (Plenum, NY, 1977), p 51. Also
presented at National ACS Meeting.
“Nematic-Like Flow Behavior in a Non-Steroidal
Cholesteric Mesophase”, Emil M Friedman and Roger S Porter, Molecular
“Polymer Viscosity-Molecular Weight Distribution
Correlations via Blending…”, Emil M Friedman and Roger S Porter, Transactions of the Society of Rheology, 49,
493, (1975). http://dx.doi.org/10.1122/1.549382
“Effect of a
Cholesteric Texture on X-ray Diffraction…Liquid Crystalline Polypeptides”, Emil
M Friedman and Ryong-Joon Roe, Molecular
“