Emil M Friedman, PhD, Statistical Consultant

Hillside, NJ

Waterbury, CT

216-287-0821

www.statisticalconsulting.org

emilfriedman@gmail.com
http://www.linkedin.com/in/emilfriedman

 

SUMMARY:

 

BS from M.I.T,     PhD from Princeton,     MS from Case Western

Experienced statistician - strong background in chemistry, polymer science & engineering.

Consulting projects have covered wide variety of (often unique) situations.

Calculated odds for various promotional games.  Devised new games.

Internal statistical consultant for R&D and manufacturing plants.  Led collaborative teams to:

           define questions and design experiments to answer them,

           improve processes & products,

           diagnose & solve wide range of technical & quality problems,

           remove unnecessary constraints and work around necessary ones.

Devised curriculum & successfully taught applied statistics in industry and online.

Extensive experience with JMP, SAS, and other software.

Extensive experience with wide variety of statistical methods.

 

EXPERIENCE:

 

Independent statistical consultant                                                                                    2003 - now

·         Calculated odds of winning various promotional games.  Devised new games.

·         Designed & analyzed experiments to test new method of removing secretions from endotracheal tubes.

·         Designed & analyzed trials to prevent infection by Israel Acute Paralysis Virus.

·         Interpreted statistical aspects of DNA data for counsel in criminal trial.

·         Identified unexpected spatial component in agricultural data. 
http://statisticalconsulting.org/Shafir.pdf

·         Designed and analyzed experiments related to smoke density & heat release (Schneller, Inc).

·         Statistically modeled market prices for Booz-Allen-Hamilton.

·         Cluster and related analyses for marketing firm.

·         Distributional analysis for jitter in oscilloscopes.

·         Modeled tire aging for Akron Rubber Development Lab (analogous to Rx stability below).


MannKind Corporation, Danbury, CT                                                                            2007 - 2015
Sr Principal Scientist, Principal Scientist, Statistician

·         Performed statistical analyses & consulted on study designs that supported regulatory submissions, ensured defensibility to external scrutiny, manufacturing, analytics, etc

·         Rapid Microbial Tests with Substantially Improved Statistical Properties (see publications)

·         Devised methods to extrapolate shelf life under multiple storage conditions (see publications)

·         Design & analysis of experiments.  Taught courses in same.

·         “Extremely complex problems of diverse scope…”

·         Representative to IPAC-RS Delivered Dose Uniformity (DDU) Working Group

 
Contract statistician assigned to Bristol-Myers Squibb, New Brunswick, NJ                2006 - 2007

·         Design of experiments & multiple criteria optimization for chemical processes.                        

·         Mathematically modeled continuous process wherein API was in the tablet coating.

·         Devised ad hoc sampling plan for unusual situation faced by other statisticians.

·         Modeled pharmaceutical stability, set tolerance intervals, recommended methodologies, etc.

·         Validated complex SAS program for Peto-Pike carcinogenicity studies. 

 

Keiser College – Online Adjunct Professor (Statistics)                                                  2004 - 2007

SAS Institute, Contract Instructor (Statistics Using JMP Software)                              2003 - 2005

 

Goodyear Tire & Rubber, Research Div, Akron, OH, Technical ladder positions         1974 - 2003

“Goodyear Spirit Award”, 1989.

 

Quotes from performance appraisals:  “…recognized and much-sought internal consultant and expert in statistical methods and their application to real problem solving….Excellent listener and dissector of the key needs/wishes of his customers….Focuses their work to answer their desired questions, and creates experimental approaches specific to each problem.”  “Emil has internalized the principals of Total Quality Culture”.

 

·         Chaired curriculum committee.  Developed, wrote and taught many portions of internal statistics courses, including workshop in Multiple Criteria Optimization.  Associates consistently said that I made previously difficult concepts easy to understand.

·         Reduced measurement variation in production process by a factor of 10.

·         Identified root cause of expensive adhesion difficulties.

·         Prevented expensive (>$500,000/yr) & unnecessary change in bladder compound.

·         Invented and developed emulsion polymers & polymer processes to satisfy product needs.

·         Extensive use of a wide variety of statistical methods (eg, designed experiments, linear & non-linear regression, assessing measurement systems, sources of variation, Multiple Criteria Optimization, happenstance data, mixed models, ANOVA, ANOCOVA).

·         Identified root causes of major polymer deficiencies and devised improvements.

·         Synthesized polymers to meet specific needs.     

·         Software development as needed.

 

Polymer Science Dept, Univ of Mass (Roger S Porter), Post-doctoral research position,  1973 - 74

Regional Chair, MIT Educational Council                                                                            ? - 2005

Cleveland VA Medical Center – Animal Care and Use Committee                                          2005
Math tutor - supposedly “lost” students achieved A’s in 11th grade math.                               2004

U. S. PATENTS:

4,254013  4,574,140  4,960,819  5,162,425

 

PRESENTATIONS:

 

Invited speaker, ASM International (Akron Chapter), Akron Rubber Group Lecture Series (twice), national meeting of American Chemical Society.  Many internal seminars.

 

PUBLICATIONS:

“Non-Transitivity, Correlation and Causation”, Emil M Friedman.  (2015) The American Statistician, 69:3, 257, http://www.tandfonline.com/eprint/wnpZDGAnFJh3cEuGZcen/full

 “In-Process Microbial Testing:  Statistical Properties of a Rapid Alternative to Compendial Enumeration Methods”, Emil M. Friedman, Mark Warner, Sam C. Shum, Fred Adair.  PDA Journal of Pharmaceutical Science and Technology, Vol 69, 264-269 (2015)  http://statisticalconsulting.org/PDAJournal2015Friedman264-9.pdf

"Challenges and Opportunities in Implementing the FDA Default Parametric Tolerance Interval Two-One Sided Test for Delivered Dose Uniformity of Orally Inhaled Products", Greg Larner, Andrew Cooper, Svetlana Lyapustina, Stefan Leiner, David Christopher, Helen Strickland, Michael Golden, Hans-Joachim Delzeit, Emil M. Friedman.  AAPS PharmaSciTech. Vol 12, 1144-56 (2011) http://www.ncbi.nlm.nih.gov/pubmed/21901649.

 “Stability Models for Sequential Storage”, Emil M Friedman and Sam C Shum.  AAPS PharmaSciTech , vol 12, pp 96-103 (2011).  DOI 10.1208/s12249-010-9558-x. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066345/)  Poster by Emil M Friedman at 33rd Annual Midwest Biopharmaceutical Statistics Workshop, Muncie, Indiana, May 24-26, 2010.

“Inspiratory Efforts Achieved in Use of the Technosphere® Insulin Inhalation System”, Chad C Smutney, Emil M Friedman, John M Polidoro and Nikhil Amin, Journal of Diabetes Science and Technology, vol 3, issue 5, Sept, 2009.  (http://www.ncbi.nlm.nih.gov/pubmed/20144434

“NIR Chemical Imaging to Guide/Support BMS-561389 Tablet Formulation Development”, L. Hilden, C.J. Pommiera, S. Badawya, Emil M. Friedman, International Journal of Pharmaceutics, 353(1-2), 283 (2008).  http://dx.doi.org/10.1016/j.ijpharm.2007.11.032

“Modality of Molecular Weight Distributions”, Emil M Friedman, Polymer Engineering and Science, 30, 569 (1990).  http://dx.doi.org/10.1002/pen.760301002  

“High Conversion Emulsion Polymerization in a Continuous Reactor:  Predictions Using Smith-Ewart Kinetics”, Emil M Friedman, J Polymer Sci, Polym Phys Ed, 18, 1771 (1980).  http://dx.doi.org/10.1002/pol.1980.180180809

“Elastomer Blends – Improved Strength…of Uncured Rubber Compounds”, Emil M Friedman, Richard G Bauer, and Diego C Rubio, in Polymer Alloys, ed D Klempner and K C Frisch (Plenum, NY, 1977), p 51.  Also presented at National ACS Meeting.

“Nematic-Like Flow Behavior in a Non-Steroidal Cholesteric Mesophase”, Emil M Friedman and Roger S Porter, Molecular Crystals and Liquid Crystals, 31, 47 (1975).  http://www.informaworld.com/smpp/content~db=all~content=a772880059

“Polymer Viscosity-Molecular Weight Distribution Correlations via Blending…”, Emil M Friedman and Roger S Porter, Transactions of the Society of Rheology, 49, 493, (1975).  http://dx.doi.org/10.1122/1.549382

“Effect of a Cholesteric Texture on X-ray Diffraction…Liquid Crystalline Polypeptides”, Emil M Friedman and Ryong-Joon Roe, Molecular Crystals and Liquid Crystals, 28, 437 (1974).

Solid State Morphology…Polypeptide Films”, Emil M Friedman, Courtney Anderson, Ryong-Joon Roe, and Arthur V Tobolsky, J Polymer Science, Polym Letters Ed, 10, 839 (1972).  http://onlinelibrary.wiley.com/doi/10.1002/pol.1972.130101104/abstract

 

EDUCATION:

Massachusetts Institute of Technology, Chemical Physics, BS.                                                1968

Princeton University, Chemistry, MA, PhD, Chemistry. (Arthur V Tobolsky, supervisor)       1973

Case Western Reserve University, Applied Statistics, MS.                                                       1987